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NIH Aug 15, 2007 | R01
African American Participation in Cancer Genetics Research
Institution: University of Pennsylvania
FOA Number: PA-04-050
Abstract
Despite significant efforts, African Americans continue to experience excess rates of morbidity and mortality from all forms of cancer relative to individuals from other ethnic and racial groups. Research is now being conducted to the molecular basis of cancer through genetic-based studies and to translate this information into strategies for cancer detection, prevention, and treatment. African American reluctance to participate in cancer genetics research will significantly limit efforts to apply these approaches to address racial disparities in cancer outcomes. To develop effective strategies for recruiting African Americans to participate in cancer genetics research and to enhance decisions about participation in this population, empirical data are needed on attitudes and beliefs that act as barriers and facilitators to participation. Studies are also needed to determine how barriers and facilitators may interact with attributes of the study to influence participation within this population. To address these gaps in our knowledge, the specific aims of this mixed methods study are to (1) identify barriers and facilitators to African American participation in cancer genetics research and to translate this information into a psychometrically sound instrument; (2) evaluate within group variation in barriers and facilitators among African Americans based on sociodemographics, experiences with disease, and cultural beliefs and values; and (3) evaluate the associations between participation intentions and two potential influences that include the attributes of the study and barriers and facilitators. The study will be implemented in three Phases and will include African American men and women ages 18-75. In Phase I, we will use qualitative methods to identify barriers and facilitators to participate in cancer genetics research.
Phase II will consist of a cross-sectional survey to evaluate within group variation in participation barriers and facilitators based on sociodemographics, experiences with disease, and cultural beliefs and values. In Phase III, we will conduct a conjoint survey to evaluate the relative influence of participation barriers and facilitators and attributes of the study on willingness to enroll in cancer genetics research. To accomplish these goals, we have assembled a team of highly qualified investigators who are experts in the application of qualitative and quantitative methods to minority recruitment, cancer genetics, psychometrics, survey research, conjoint analysis. This study will provide empirical data that can be used to develop more effective strategies for recruiting African Americans to participate in cancer genetics research that enhance decisions about study participation.
FUNDING AGENCY:
Funder:
NIHInstitute:
NATIONAL HUMAN GENOME RESEARCH INSTITUTEFunding Type:
R01Project Number:
R01HG004346Start Date:
Aug 15, 2007End Date:
Jun 30, 2010PROJECT TERMS:
African American, Age, Altruism, Atlases, Attitude, base, Belief, Benefits and Risks, Cancer Detection, cancer genetics, cancer genome, Characteristics, Clinical, Clinical Medicine, Clinical Research, contextual factors, Counseling, Cross-Sectional Studies, Data, Decision Making, Development, Disease, Education, Enrollment, Ethnic Origin, expectation, experience, Exposure to, Family history of, Future, gene environment interaction, Genes, Genetic, Genetic Research, Genome, genome sequencing, Genomics, Goals, Healthcare, Human, Human Genome, Human Genome Project, Income, Individual, instrument, Knowledge, Learning, Malignant Neoplasms, Medicine, men, Methods, Minority, Minority Groups, Molecular, Morals, Morbidity - disease rate, mortality, Mutation, National Cancer Institute, Nature, Outcome, Perception, Persons, Phase, Play, Population, Populations at Risk, Prevention, Procedures, programs, Property, Psychometrics, Qualifying, Qualitative Methods, Race, racial discrimination, Rate, Recruitment Activity, Relative (related person), Religion and Spirituality, Reporting, Research, Research Design, Research Institute, Research Personnel, Risk, Role, Scientific Advances and Accomplishments, Somatic Mutation, sound, Surveys, Technology, Testing, Translating, tumor, Variant, willingness, Woman