ELSI in Review • April 2023

About this listing

ELSI in Review is a listing of recently published reviews of the literature on key ELSI topics curated by CERA staff. Our April 2023 set explores AI innovations in the Tanzanian health sector, uses of blockchain in genomics, and more. If you would like your ELSI-relevant review featured in this communication, please contact us at [email protected]. You can find more reviews in the ELSIhub Publications database!

Artificial Intelligence

• Morgan, M. B., & Mates, J. L. (2023). Ethics of artificial intelligence in breast imaging. Journal of Breast Imaging, Article wbac076.
• Sukums, F., Mzurikwao, D., Sabas, D., Chaula, R., Mbuke, J., Kabika, T., Kaswija, J., Ngowi, B., Noll, J., Winkler, A. S., & Andersson, S. W. (2023). The use of artificial intelligence-based innovations in the health sector in Tanzania: A scoping review. Health Policy and Technology, 12(1), Article e100728.
• Chen, I. Y., Pierson, E., Rose, S., Joshi, S., Ferryman, K., & Ghassemi, M. (2021). Ethical machine learning in healthcare. Annual Review of Biomedical Data Science, 4, 123–144.

Cancer Genomics

• Bartley, N., Napier, C., Best, M., & Butow, P. (2020). Patient experience of uncertainty in cancer genomics: A systematic review. Genetics in Medicine, 22(9), 1450–1460.
• Taylor, L. C., Law, K., Hutchinson, A., Dennison, R. A., & Usher-Smith, J. A. (2023). Acceptability of risk stratification within population-based cancer screening from the perspective of healthcare professionals: A mixed methods systematic review and recommendations to support implementation. PLOS ONE, 18(2), Article e0279201.
• Bokkers, K., Vlaming, M., Engelhardt, E. G., Zweemer, R. P., van Oort, I. M., Kiemeney, L. A., Bleiker, E. M. A., & Ausems, M. G. (2022). The feasibility of implementing mainstream germline genetic testing in routine cancer care—A systematic review. Cancers, 14(4), Article e1059.

Underrepresented Populations

• Southwick, S. V., Esch, R., Gasser, R., Cragun, D., Redlinger-Grosse, K., Marsalis, S., & Zierhut, H. A. (2020). Racial and ethnic differences in genetic counseling experiences and outcomes in the United States: A systematic review. Journal of Genetic Counseling, 29(2), 147–165.
• Bolleddula, J., Simeon, D., Anderson, S. G., Shields, L., Mullings, J., Ossorio, P., Bethelmey, A., & Perkins, A. K. (2022). No person left behind: Mapping the health policy landscape for genomics research in the Caribbean. The Lancet Regional Health - Americas, 15, Article e100367.
• Tawfik, S. M., Elhosseiny, A. A., Galal, A. A., William, M. B., Qansuwa, E., Elbaz, R. M., & Salama, M. (2023). Health inequity in genomic personalized medicine in underrepresented populations: A look at the current evidence. Functional & Integrative Genomics, 23, Article 54.
• D’Gama, A. M., & Agrawal, P. B. (2023). Role of genomic medicine and implementing equitable access for critically ill infants in neonatal intensive care units. Journal of Perinatology.

Population-based Screening

• Alarcón Garavito, G. A., Moniz, T., Déom, N., Redin, F., Pichini, A., & Vindrola-Padros, C. (2022). The implementation of large-scale genomic screening or diagnostic programmes: A rapid evidence review. European Journal of Human Genetics, 31, 282–295.
• Williams, M. S. (2022). Population screening in health systems. Annual Review of Genomics and Human Genetics, 23, 549–567.
• Lacaze, P., Manchanda, R., & Green, R. C. (2023). Prioritizing the detection of rare pathogenic variants in population screening. Nature Reviews Genetics. Advance online publication.
• Rink, B. D. (2023). Informed consent for expanded carrier screening: Past, present, and future. Prenatal Diagnosis. Advance online publication.
• Goldberg, J. D., Pierson, S., & Johansen Taber, K. (2023). Expanded carrier screening: What conditions should we screen for?. Prenatal Diagnosis. Advance online publication.

Genomic Data Privacy, Control, and Ownership

• Dhirani, L. L., Mukhtiar, N., Chowdhry, B. S., & Newe, T. (2023). Ethical dilemmas and privacy issues in emerging technologies: A review. Sensors, 23(3), 1151.
• Alghazwi, M., Turkmen, F., Van Der Velde, J., & Karastoyanova, D. (2022). Blockchain for genomics: A systematic literature review. Distributed Ledger Technologies: Research and Practice, 1(2), 1–28.
• Alvarellos, M., Sheppard, H. E., Knarston, I., Davison, C., Raine, N., Seeger, T., Prieto Barja, P., & Chatzou Dunford, M. (2023). Democratizing clinical-genomic data: How federated platforms can promote benefits sharing in genomics. Frontiers in Genetics, 13, Article e1045450.