ELSI in Review • April 2024

About this listing

ELSI in Review is a listing of recently published reviews of the literature on key ELSI topics curated by CERA staff. Our April 2024 set explores precision microbiome engineering, PGT for hereditary cancer, incidental findings in forensic investigations, and more. If you would like your ELSI-relevant review featured in this communication, please contact us at [email protected]. You can find more reviews in the ELSIhub Publications database!

Knowledge, Attitudes, and Beliefs

• Estevan-Ortega, M., de la Encarnación Castellano, C., Mendiola-López, A., Parker, L. A., Caballero-Romeu, J. P., & Lumbreras, B. (2024). Urologists’ and general practitioners’ knowledge, beliefs and practice relevant for opportunistic prostate cancer screening: A PRISMA-compliant systematic review. Frontiers in Medicine, 11, Article 1283654.
• Gatt-Rutter, T., Forrest, L., Sexton, A., & Isbister, J. (2024). Consumer attitudes and preferences toward psychiatric genetic counselling and educational resources: A scoping review. Patient Education and Counseling, 123, Article 108229.
• Moore, C., Lazarakis, S., Stenta, T., Alexander, M., Nguyen, R. P., Elliott, D. A., & Conyers, R. (2023). A systematic review of knowledge, attitude and practice of pharmacogenomics in pediatric oncology patients. Pharmacology Research & Perspectives, 11(6), Article e01150.
• Pearce, A., Mitchell, L. A., Best, S., Young, M.-A., & Terrill, B. (2024). Publics’ knowledge of, attitude to and motivation towards health-related genomics: A scoping review. European Journal of Human Genetics. Advance online publication.
• Walshe, J., Elphinstone, B., Nicol, D., & Taylor, M. (2024). A systematic literature review of the ‘commercialisation effect’ on public attitudes towards biobank and genomic data repositories. Public Understanding of Science. Advance online publication.

Legal Considerations

• Sherkow, J. S., Cook-Deegan, R., & Greely, H. T. (2024). The Myriad Decision at 10. Annual Review of Genomics and Human Genetics, 25. Advance online publication.
• Callahan, K. P., Clayton, E. W., Lemke, A. A., Chaudhari, B. P., Wenger, T. L., Lyle, A. N. J., & Brothers, K. B. (2024). Ethical and legal issues surrounding genetic testing in the NICU. NeoReviews, 25(3), e127–e138.
• Cucinella, G., Gullo, G., Catania, E., Perino, A., Billone, V., Marinelli, S., Napoletano, G., & Zaami, S. (2024). Stem cells and infertility: A review of clinical applications and legal frameworks. Journal of Personalized Medicine, 14(2), Article 135.

Genetic Testing

• Andreoli, L., Peeters, H., Van Steen, K., & Dierickx, K. (2024). Taking the risk. A systematic review of ethical reasons and moral arguments in the clinical use of polygenic risk scores. American Journal of Medical Genetics Part A, Article e63584. Advance online publication.
• Albujja, M. H., Al-Ghedan, M., Dakshnamoorthy, L., & Victori, J. P. (2024). Preimplantation genetic testing for embryos predisposed to hereditary cancer: Possibilities and challenges. Cancer Pathogenesis and Therapy, 2(1), 1–14.
• Latham, K. E. (2024). Preimplantation genetic testing: A remarkable history of pioneering, technical challenges, innovations, and ethical considerations. Molecular Reproduction and Development, 91(1), Article e23727.

Gene Therapy and Genetic Engineering

• Hardwick, A., Cummings, C., Graves, J., & Kuzma, J. (2024). Can societal and ethical implications of precision microbiome engineering be applied to the built environment? A systematic review of the literature. Environment Systems and Decisions. Advance online publication.
• D’Souza, R. F., Mathew, M., & Surapaneni, K. M. (2023). A scoping review on the ethical issues in the use of CRISPR-Cas9 in the creation of human disease models. Journal of Clinical and Diagnostic Research, 17(12), JE01–JE08.
• Kimberly, L., Hunt, C., Beaverson, K., James, E., Bateman-House, A., McGowan, R., & DeSante-Bertkau, J. (2023). The lived experience of pediatric gene therapy: A scoping review. Human Gene Therapy, 34(23–24), 1180–1189.

Informed Consent

• Dalal, V., Jotwani, G., & Yadav, M. L. (2024). Redefining informed consent form in cell and gene therapy trials. Perspectives in Clinical Research, 15(1), 4–9.
• Fasani, G., Gino, S., & Sguazzi, G. (2023). Incidental findings in forensic investigations: A narrative review. Forensic Sciences, 3(2), 345–356.
• Lee, A. R., Koo, D., Kim, I. K., Lee, E., Kim, H. H., Yoo, S., Kim, J.-H., Choi, E. K., & Lee, H.-Y. (2023). Identifying facilitators of and barriers to the adoption of dynamic consent in digital health ecosystems: A scoping review. BMC Medical Ethics, 24(1), 107.