ELSI in Review • April 2025

About this listing

ELSI in Review is a listing of recently published reviews of the literature on key ELSI topics curated by CERA staff. Our April 2025 set explores ethical considerations of prenatal gene editing for neurodevelopmental diseases, factors that influence parents’ decisions regarding pediatric genetic testing, and more. If you would like your ELSI-relevant review featured in this communication, please contact us at [email protected]. You can find more reviews in the ELSIhub Publications database!

Gene Therapy and Gene Editing

• van Hooff, L. C., Merz, E.-M., Kidane Gebremeskel, A. S., de Jong, J. A., Burchell, G. L., & Lunshof, J. E. (2025). Balancing benefits and burdens: A systematic review on ethical and social dimensions of gene and cell therapies for hereditary blood diseases. BMC Medical Ethics, 26, Article 36.
• Cohen, I. G., & Adashi, E. Y. (2025). Ethical and legal implications of in vitro gametogenesis and germline editing—Current status. Fertility and Sterility. Advance online publication.
• Major, R. M., & Juengst, E. T. (2025). Prenatal gene editing for neurodevelopmental diseases: Ethical considerations. The American Journal of Human Genetics, 112(2), 201–214.
• Puthumana, J., Chandrababu, A., Sarasan, M., Joseph, V., & Singh, I. S. B. (2024). Genetic improvement in edible fish: Status, constraints, and prospects on CRISPR-based genome engineering. 3 Biotech, 14, Article 44.

Genomics in Africa

• Munung, N. S. (2025). Science and society: Pathways to equitable access and delivery of genomics medicine in Africa. Current Genetic Medicine Reports, 13, Article 1.
• Olajide, T., Okeke, S., Joshua, I., Femi-Lawal, V., Ogungbemi, E., Alemenzohu, H., Asogwa, C., Babawale, I., Olajide, G., Michael, A., Babawale, D., Olawoye, O., Akinrinde, D., Ogundele, T., Ogundijo, D., Chikere, N., Ala, O., Akano, O., Adeoti, S., … Akinyemi, R. (2025). Stroke neurobiobanking and genomic research in Africa: A narrative review. The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 61, Article 14.
• Sadikiel Mmbando, G. (2024). The adoption of genetically modified crops in Africa: The public’s current perception, the regulatory obstacles, and ethical challenges. GM Crops & Food, 15(1), 185–199.

Artificial Intelligence

• Boudi, A. L., Boudi, M., Chan, C., Boudi, F. B., Boudi, A., Boudi, M., Chan, C., & Boudi, F. B. (2024). Ethical challenges of artificial intelligence in medicine. Cureus, 16(11), Article e74495.
• Shanmugam, D., Agrawal, M., Movva, R., Chen, I. Y., Ghassemi, M., Jacobs, M., & Pierson, E. (2025). Generative artificial intelligence in medicine.  Annual Review of Biomedical Data Science. Advance online publication.

Precision Health

• Roberts, M. C., Holt, K. E., Del Fiol, G., Baccarelli, A. A., & Allen, C. G. (2024). Precision public health in the era of genomics and big data. Nature Medicine, 30(7), 1865–1873.
• Mubarak, S., & Ashraf, M. (2024). Ethics considerations for precision medicine research and genetic testing in low- and middle-income countries. Eastern Mediterranean Health Journal, 30(6), 455–460.
• Bastaki, K., Velayutham, D., Irfan, A., Adnan, M., Mohammed, S., Mbarek, H., Qoronfleh, M. W., & Jithesh, P. V. (2024). Forging the path to precision medicine in Qatar: A public health perspective on pharmacogenomics initiatives. Frontiers in Public Health, 12, Article 1364221.
• Kalidasan, V., & Theva Das, K. (2024). Advancing precision medicine with gene and cell therapy in Malaysia: Ethical, legal, and social implications. Human Gene Therapy, 35(1–2), 9–25.

Genetic Testing and Screening

• Doll, E. S., Lerch, S. P., Schmalenberger, K. M., Alex, K., Kölker, S., Brennenstuhl, H., Pereira, S., Smith, H., Winkler, E. C., Mahal, J., & Ditzen, B. (2025). How do parents decide on genetic testing in pediatrics? A systematic review. Genetics in Medicine. Advance online publication.
• Ross, L. F., & Ormond, K. E. (2025). Newborn sequencing: The promise and perils. Annual Review of Genomics and Human Genetics. Advance online publication.