ELSI in Review • January 2024

About this listing

ELSI in Review is a listing of recently published reviews of the literature on key ELSI topics curated by CERA staff. Our January 2024 set explores experiences with genetic testing for autism spectrum disorders, bioethics of somatic gene therapy, and more. If you would like your ELSI-relevant review featured in this communication, please contact us at [email protected]. You can find more reviews in the ELSIhub Publications database!

Genetic Testing

• Kim, S., Pistawka, C., Langlois, S., Osiovich, H., Virani, A., Kitchin, V., GenCOUNSEL Study, & Elliott, A. M. (2023). Genetic counselling considerations with genetic/genomic testing in Neonatal and Pediatric Intensive Care Units: A scoping review. Clinical Genetics. Advance online publication.
• Miller, E. G., Young, J. L., Rao, A., Ward-Lev, E., & Halley, M. C. (2023). Demographic characteristics associated with perceptions of personal utility in genetic and genomic testing: A systematic review. JAMA Network Open, 6(5), Article e2310367.
• VerStrate, C. A., & Mahon, S. M. (2023). Direct-to-consumer genomic testing through an ethics lens: Oncology nursing considerations. Clinical Journal of Oncology Nursing, 27(4), 380–388.
• Zhou, M., Zhang, Y.-M., & Li, T. (2023). Knowledge, attitudes and experiences of genetic testing for autism spectrum disorders among caregivers, patients, and health providers: A systematic review. World Journal of Psychiatry, 13(5), 247–261.

Polygenic Risk Scores

• Fatumo, S., Sathan, D., Samtal, C., Isewon, I., Tamuhla, T., Soremekun, C., Jafali, J., Panji, S., Tiffin, N., & Fakim, Y. J. (2023). Polygenic risk scores for disease risk prediction in Africa: Current challenges and future directions. Genome Medicine, 15(1), Article 87.
• Fritzsche, M.-C., Akyüz, K., Cano Abadía, M., McLennan, S., Marttinen, P., Mayrhofer, M. Th., & Buyx, A. M. (2023). Ethical layering in AI-driven polygenic risk scores—New complexities, new challenges. Frontiers in Genetics, 14.
• Kachuri, L., Chatterjee, N., Hirbo, J., Schaid, D. J., Martin, I., Kullo, I. J., Kenny, E. E., Pasaniuc, B., Witte, J. S., & Ge, T. (2023). Principles and methods for transferring polygenic risk scores across global populations. Nature Reviews Genetics, 25, 8–25.

Gene Therapy

• Buedo, P., Bianchini, A., Klas, K., & Waligora, M. (2023). Bioethics of somatic gene therapy: What do we know so far? Current Medical Research and Opinion, 39(10), 1355–1365.
• Niazi, S. K. (2023). The dawn of in vivo gene editing era: A revolution in the making. Biologics, 3(4), 253–295.
• Segers, S. (2023). Heritable genome editing: Ethical aspects of a developing domain. Human Reproduction, 38(11), 2055–2061.

Gene Editing

• Raban, R., Marshall, J. M., Hay, B. A., & Akbari, O. S. (2023). Manipulating the destiny of wild populations using CRISPR. Annual Review of Genetics, 57(1), 361–390.
• James, S. L., Dass, B., & Quemada, H. (2023). Regulatory and policy considerations for the implementation of gene drive-modified mosquitoes to prevent malaria transmission. Transgenic Research, 32(1), 17–32.