ELSI in Review • January 2025

About this listing

ELSI in Review is a listing of recently published reviews of the literature on key ELSI topics curated by CERA staff. Our January 2025 set explores public perceptions of genetic engineering, ethical issues in healthcare artificial intelligence, and more. If you would like your ELSI-relevant review featured in this communication, please contact us at [email protected]. You can find more reviews in the ELSIhub Publications database!

Gene Editing

• Geuverink, W. P., Houtman, D., Retel Helmrich, I. R. A., Kist, J. D., Henneman, L., Cornel, M. C., & Riedijk, S. R. (2024). A decade of public engagement regarding human germline gene editing: A systematic scoping review. European Journal of Human Genetics. Advance online publication.
• Liaw, Y.-Q. (2024). An analysis of different concepts of “identity” in the heritable genome editing debate. Medicine, Health Care and Philosophy, 27(1), 121–131.
• Schambach, A., Buchholz, C. J., Torres-Ruiz, R., Cichutek, K., Morgan, M., Trapani, I., & Büning, H. (2024). A new age of precision gene therapy. The Lancet, 403(10426), 568–582.
• Ramos, P. D., Almeida, M. S., & Olsson, I. A. S. (2023). What do people think about genetic engineering? A systematic review of questionnaire surveys before and after the introduction of CRISPR. Frontiers in Genome Editing, 5, Article 1284547.

Clinical Genetics

• Andreoli, L., Peeters, H., Van Steen, K., & Dierickx, K. (2024). Polygenic risk scores in the clinic: A systematic review of stakeholders’ perspectives, attitudes, and experiences. European Journal of Human Genetics. Advance online publication.
• Vendrell, X., Abulí, A., Serra, C., Guillén, J. J., Rueda, J., García-Planells, J., Santos-Simarro, F., Quiroga, R., Abellán, F., Oancea-Ionescu, R., & Guillén-Navarro, E. (2024). Population-based genetic carrier screening. A consensus statement from the Spanish societies: AEGH, AEDP, ASEBIR, SEAGEN, SEF and SEGCD. European Journal of Human Genetics. Advance online publication.
• Howard, J., Chaouch, A., Douglas, A. G. L., MacLeod, R., Roggenbuck, J., & McNeill, A. (2024). Genetic testing for monogenic forms of motor neuron disease/amyotrophic lateral sclerosis in unaffected family members. European Journal of Human Genetics. Advance online publication.

Biobanking

• Capasso, E., Casella, C., Marisei, M., Tortora, M., Briganti, F., & Di Lorenzo, P. (2024). Imaging biobanks: Operational limits, medical-legal and ethical reflections. Frontiers in Digital Health, 6, Article 1408619.
• Gallagher, C. S., Ginsburg, G. S., & Musick, A. (2024). Biobanking with genetics shapes precision medicine and global health. Nature Reviews Genetics. Advance online publication.

Artificial Intelligence

• Collins, B. X., Bélisle-Pipon, J.-C., Evans, B. J., Ferryman, K., Jiang, X., Nebeker, C., Novak, L., Roberts, K., Were, M., Yin, Z., Ravitsky, V., Coco, J., Hendricks-Sturrup, R., Williams, I., Clayton, E. W., Malin, B. A., & Bridge2AI Ethics and Trustworthy AI Working Group. (2024). Addressing ethical issues in healthcare artificial intelligence using a lifecycle-informed process. JAMIA Open, 7(4), Article ooae108.
• Wang, L., Wan, Z., Ni, C., Song, Q., Li, Y., Clayton, E., Malin, B., & Yin, Z. (2024). Applications and concerns of ChatGPT and other conversational large language models in health care: Systematic review. Journal of Medical Internet Research, 26(1), Article e22769.