ELSI in Review • July 2025

About this listing

ELSI in Review is a listing of recently published reviews of the literature on key ELSI topics curated by CERA staff. Our July 2025 set explores ethical issues in the use of genetic predictions of aggressive behavior in the criminal justice system, applying artificial intelligence in healthcare, and more. If you would like your ELSI-relevant review featured in this communication, please contact us at [email protected]. You can find more reviews in the ELSIhub Publications database!

Communicating Genetic Test Results

• Seidi, C., Sousa, L., & Mendes, Á. (2025). Genetic health professionals’ facilitation of communication between parents and young children about inherited genetic conditions: A scoping review. Journal of Genetic Counseling, 34(3), Article e70000.
• Fontoura Dias, S., Barbosa, M., Júlio, F., Clarke, A., Metcalfe, A., Sequeiros, J., Paneque, M., Sousa, L., & Mendes, Á. (2025). Communicating genetic information in families with inherited late-onset neurodegenerative diseases: A scoping review. Health Communication. Advance online publication.
• Hanley, M., Limb, S., Purvis, R., Saya, S., James, P. A., & Forrest, L. E. (2025). The development and evaluation of polygenic risk score reports: A systematized review of the literature. Genetics in Medicine, 27(7), Article 101426.
• Pezzullo, A. M., Valz Gris, A., Scarsi, N., Tona, D. M., Porcelli, M., Di Pumpo, M., Piko, P., Adany, R., Kannan, P., Perola, M., Cardoso, M. L., Costa, A., Vicente, A. M., Reigo, A., Vaht, M., Metspalu, A., Kroese, M., Pastorino, R., & Boccia, S. (2025). A scoping review of the assessment reports of genetic or genomic tests reveals inconsistent consideration of key dimensions of clinical utility. Journal of Clinical Epidemiology, 181, Article 111729.

Artificial Intelligence

• Ratti, E., Morrison, M., & Jakab, I. (2025). Ethical and social considerations of applying artificial intelligence in healthcare—A two-pronged scoping review. BMC Medical Ethics, 26(1), Article 68.
• Habibi, F., Ghaderkhani, S., Shokoohi, M., Banari, T., Morsali, M., Abadi, R. N. S., & Kiamehr, H. (2025). Harnessing artificial intelligence in Alzheimer’s disease management: Navigating ethical challenges in AI. AI and Ethics. Advance online publication.

Mental Health

• Refolo, P., Ferracuti, S., Grassi, S., Raimondi, C., Mercuri, G., Zedda, M., Aulino, G., Spagnolo, A. G., & Oliva, A. (2025). Ethical issues in the use of genetic predictions of aggressive behavior in the criminal justice system: A systematic review. Frontiers in Genetics, 16, Article 1599750.
• Neiders, I., Mežinska, S., & van Haren, N. E. M. (2025). Ethical and social issues in prediction of risk of severe mental illness: A scoping review and thematic analysis. BMC Psychiatry, 25(1), Article 501.
• Dane, A., Berkman, J., DeBortoli, E., Wallingford, C. K., Yanes, T., & McInerney-Leo, A. (2025). Narrative therapy and family therapy in genetic counseling: A scoping review. Journal of Genetic Counseling, 34(2), Article e1938.
• Strasser, S., McDonald, I. R., Uveges, M. K., Hesse-Biber, S., Keels, J., Smith, N., & Dwyer, A. A. (2025). Psychosocial factors Involved in genetic testing for rare diseases: A scoping review. Genes, 16(6), Article 6.

Genomic Data

• Lehmann, B., Bräuninger, L., Cho, Y., Falck, F., Jayadeva, S., Katell, M., Nguyen, T., Perini, A., Tallman, S., Mackintosh, M., Silver, M., Kuchenbäcker, K., Leslie, D., Chatterjee, N., & Holmes, C. (2025). Methodological opportunities in genomic data analysis to advance health equity. Nature Reviews Genetics. Advance online publication.
• Lukhele, S. T., Ras, V., & Mulder, N. (2025). Workforce development in genomic data science for health: A worldview. Annual Review of Genomics and Human Genetics. Advance online publication.