ELSI in Review • May 2023

About this listing

ELSI in Review is a listing of recently published reviews of the literature on key ELSI topics curated by CERA staff. Our May 2023 set explores the utility of ChatGPT in healthcare, the ethics of genetic prioritization for COVID-19 vaccines, and more. If you would like your ELSI-relevant review featured in this communication, please contact us at [email protected]. You can find more reviews in the ELSIhub Publications database!

AI and Healthcare

• Sallam, M. (2023). ChatGPT utility in healthcare education, research, and practice: Systematic review on the promising perspectives and valid concerns. Healthcare, 11(6), Article 887.
• Murphy, K., Di Ruggiero, E., Upshur, R., Willison, D. J., Malhotra, N., Cai, J. C., Malhotra, N., Lui, V., & Gibson, J. (2021). Artificial intelligence for good health: A scoping review of the ethics literature. BMC Medical Ethics, 22(1), Article 14.
• Ali, O., Abdelbaki, W., Shrestha, A., Elbasi, E., Alryalat, M. A. A., & Dwivedi, Y. K. (2023). A systematic literature review of artificial intelligence in the healthcare sector: Benefits, challenges, methodologies, and functionalities. Journal of Innovation & Knowledge, 8(1), Article 100333.

Genomic Research

• Wolf, S. M., & Green, R. C. (2023). Return of results in genomic research using large-scale or whole genome sequencing: Toward a new normal. Annual Review of Genomics and Human Genetics, 24(1). Advance online publication.
• Iyer, A. A., Saade, D., Bharucha-Goebel, D., Foley, A. R., Averion, G. M., Paredes, E., Gray, S., Bönnemann, C. G., Grady, C., Hendriks, S., & Rid, A. (2021). Ethical challenges for a new generation of early-phase pediatric gene therapy trials. Genetics in Medicine, 23(11), 2057–2066.
• Safarlou, C. W., Jongsma, K. R., Vermeulen, R., & Bredenoord, A. L. (2023). The ethical aspects of exposome research: A systematic review. Exposome, Article osad004.
• Tschigg, K., Consoli, L., Biasiotto, R., & Mascalzoni, D. (2022). Ethical, legal and social/societal implications (ELSI) of recall-by-genotype (RbG) and genotype-driven-research (GDR) approaches: A scoping review. European Journal of Human Genetics, 30, 1000–1010.

Research Participation

• Taffere, G. R., Abebe, H. T., Zerihun, Z., Mallen, C., Price, H. P., & Mulugeta, A. (2023). Systematic review of community engagement approach in research: Describing partnership approaches, challenges and benefits. Journal of Public Health.
• Nathe, J. M., Oskoui, T. T., & Weiss, E. M. (2023). Parental views of facilitators and barriers to research participation: Systematic review. Pediatrics, 151(1), Article e2022058067.
• Lee, S. S.-J. (2021). The ethics of consent in a shifting genomic ecosystem. Annual Review of Biomedical Data Science, 4, 145–164.

Direct-to-Consumer Genetic Testing

• Park, J. K., & Lu, C. Y. (2023). Polygenic scores in the direct-to-consumer setting: Challenges and opportunities for a new era in consumer genetic testing. Journal of Personalized Medicine, 13(4), Article 573.
• Majumder, M. A., Guerrini, C. J., & McGuire, A. L. (2021). Direct-to-consumer genetic testing: Value and risk. Annual Review of Medicine, 72(1), 151–166.
• Nolan, J. J., & Ormondroyd, E. (2023). Direct-to-consumer genetic tests providing health risk information: A systematic review of consequences for consumers and health services. Clinical Genetics. Advance online publication.

Genomic Medicine

• Synofzik, M., van Roon-Mom, W. M. C., Marckmann, G., van Duyvenvoorde, H. A., Graessner, H., Schüle, R., Aartsma-Rus, A., & 1M1M consortium. (2022). Preparing n-of-1 antisense oligonucleotide treatments for rare neurological diseases in Europe: Genetic, regulatory, and ethical perspectives. Nucleic Acid Therapeutics, 32(2), 83–94.
• Brown, H. L., Sherburn, I. A., Gaff, C., Taylor, N., & Best, S. (2022). Structured approaches to implementation of clinical genomics: A scoping review. Genetics in Medicine, 24(7), 1415–1424.

Prenatal Testing

• Nzekwue, C., & Ogueh, O. (2023). Prenatal diagnosis and preimplantation genetic diagnosis for sickle cell disease in Africa. Journal of Global Medicine, 2(1), 75.
• Thomas, S. P., Keller, M. A., Ranson, T., & Willard, R. E. (2023). Patient perspectives on noninvasive prenatal testing among black women in the United States: A scoping review. BMC Pregnancy and Childbirth, 23(1), Article 183.
• Bowman-Smart, H., Gyngell, C., Mand, C., Amor, D. J., Delatycki, M. B., & Savulescu, J. (2023). Non-invasive prenatal testing for “non-medical” traits: Ensuring consistency in ethical decision-making. The American Journal of Bioethics, 23(3), 3–20.

Public Attitudes

• van den Heuvel, L. M., Smets, E. M. A., van Tintelen, J. P., & Christiaans, I. (2019). How to inform relatives at risk of hereditary diseases? A mixed-methods systematic review on patient attitudes. Journal of Genetic Counseling, 28(5), 1042–1058.
• Calabrò, G. E., Sassano, M., Tognetto, A., & Boccia, S. (2020). Citizens’ attitudes, knowledge, and educational needs in the field of omics sciences: A systematic literature review. Frontiers in Genetics, 11, Article 570649.
• Taylor, L. C., Hutchinson, A., Law, K., Shah, V., Usher-Smith, J. A., & Dennison, R. A. (2023). Acceptability of risk stratification within population-based cancer screening from the perspective of the general public: A mixed-methods systematic review. Health Expectations. Advance online publication.