ELSI in Review • November 2022

About this listing

ELSI in Review is a listing of recently published reviews of the literature on key ELSI topics curated by CERA staff. Our November 2022 set explores ethical considerations in precision medicine, societal implications of expanded carrier screening, and more. If you would like your ELSI-relevant review featured in this communication, please contact us at [email protected]. You can find more reviews in the ELSIhub Publications database!

Genome Editing and Gene Therapy

• Gostimskaya, I. (2022). CRISPR–Cas9: A history of its discovery and ethical considerations of its use in genome editing. Biochemistry (Moscow), 87(8), 777-788.
• Lange, V., & Kappel, K. (2022). CRISPR gene-therapy: A critical review of ethical concerns and a proposal for public decision-making. Canadian Journal of Bioethics/Revue canadienne de bioéthique, 5(2), 78-87.

Precision Medicine

• Santaló, J., & Berdasco, M. (2022). Ethical implications of epigenetics in the era of personalized medicine. Clinical Epigenetics, 14(1), 1-14.
• Evers, K. (2022). Personalized medicine in psychiatry: ethical challenges and opportunities. Dialogues in Clinical Neuroscience, 1(4), 427–434. 
• Fusar-Poli, P., Manchia, M., Koutsouleris, N., Leslie, D., Woopen, C., Calkins, M. E., Dunn, M., Le Tourneau, C., Mannikkom, M., Molleman, T., Oliver, D., Rietschel, M., Reininghaus, E. Z., Squassina, A., Valmaggia, L., Kessing, L. V., Vieta, E., Correll, C. U., Arango, C., Andreassen, O. A., & Andreassen, O. A. (2022). Ethical considerations for precision psychiatry: A roadmap for research and clinical practice. European Neuropsychopharmacology, 63, 17-34.

Data Privacy

• Wan, Z., Hazel, J. W., Clayton, E. W., Vorobeychik, Y., Kantarcioglu, M., & Malin, B. A. (2022). Sociotechnical safeguards for genomic data privacy. Nature Reviews Genetics, 23, 429–445.
• Kalkman, S., van Delden, J., Banerjee, A., Tyl, B., Mostert, M., & van Thiel, G. (2022). Patients’ and public views and attitudes towards the sharing of health data for research: A narrative review of the empirical evidence. Journal of Medical Ethics, 48(1), 3-13.

Genetic Screening

• Chad, L., Anderson, J., Cagliero, D., Hayeems, R. Z., Ly, L. G., & Szuto, A. (2022). Rapid genetic testing in pediatric and neonatal critical care: A scoping review of emerging ethical issues. Hospital Pediatrics, 12(10), 347-359.
• Charron, M., Kaiser, B., Dauge, A., Gallois, H., Lapointe, J., Dorval, M., Nabi, H., & Joly, Y. (2022). Integrating hereditary breast and ovarian cancer genetic counselling and testing into mainstream clinical practice: Legal and ethical challenges. Critical Reviews in Oncology/Hematology, 178, 103797.
• van den Heuvel, L. M., van den Berg, N., Janssens, A. C. J. W., Birnie, E., Henneman, L., Dondorp, W. J., Plantinga, M., & van Langen, I. M. (2022). Societal implications of expanded universal carrier screening: a scoping review. European Journal of Human Genetics. Advance online publication.