ELSI in Review • October 2024

About this listing

ELSI in Review is a listing of recently published reviews of the literature on key ELSI topics curated by CERA staff. Our October 2024 set explores the ethics of human embryo editing, ELSI challenges with somatic gene therapy treatment for sickle cell disease, and more. If you would like your ELSI-relevant review featured in this communication, please contact us at [email protected]. You can find more reviews in the ELSIhub Publications database!

Pharmacogenomics

• Farmaki, A., Manolopoulos, E., & Natsiavas, P. (2024). Will precision medicine meet digital health? A systematic review of pharmacogenomics clinical decision support systems used in clinical practice. OMICS: A Journal of Integrative Biology, 28(9), 442–460. 
• Lauschke, V. M., Zhou, Y., & Ingelman-Sundberg, M. (2024). Pharmacogenomics beyond single common genetic variants: The way forward. Annual Review of Pharmacology and Toxicology, 64, 33–51. 
• Medwid, S., & Kim, R. B. (2024). Implementation of pharmacogenomics: Where are we now? British Journal of Clinical Pharmacology, 90(8), 1763–1781.
• Palumbo, S., Mariotti, V., & Pellegrini, S. (2024). A narrative review on pharmacogenomics in psychiatry: Scientific definitions, principles, and practical resources. Journal of Clinical Psychopharmacology 44(1), 49–56.

Gene Therapy

• Bateman-House, A. (2024). Somatic gene therapy: ethics and access. Annual Review of Genomics and Human Genetics, 25, 421–438.
• Munung, N. S., Nnodu, O. E., Moru, P. O., Kalu, A. A., Impouma, B., Treadwell, M. J., & Wonkam, A. (2024). Looking ahead: Ethical and social challenges of somatic gene therapy for sickle cell disease in Africa. Gene Therapy, 31(5), 202–208.
• Duddu, S., Chakrabarti, R., Sharma, P., Gupta, D., & Shukla, P. C. (2024). Gene editing and therapy in acquired and inherited cardiovascular disorders. The Nucleus, 67(1), 237–250.

Cancer Genetics

• Afaya, A., Kim, S.-W., Park, H. S., Lim, M. C., Jung, M. S., Nam, E. J., Park, J. S., Jeong, J., Ryu, J. M., Kim, J., Kim, J., Kim, M., Jin, J., Han, J., Kim, S. Y., Park, S.-Y., Katapodi, M. C., Kim, S., & the K-CASCADE consortium. (2024). Psychosocial barriers and facilitators for cascade genetic testing in hereditary breast and ovarian cancer: A scoping review. Familial Cancer, 23(2), 121–132.
• Jain, M. S., Srikruthi, K. S., Goudanavar, P., & Naveen, N. R. (2024). Navigating the frontier: Comprehensive insights into CRISPR technology advancements, delivery strategies, and ethical considerations in cancer research. Oral Oncology Reports, 9, Article 100224.
• Smit, A. K., Gokoolparsadh, A., McWhirter, R., Newett, L., Milch, V., Hermes, A., McInerney-Leo, A., & Newson, A. J. (2024). Ethical, legal and social issues related to genetics and genomics in cancer: A scoping review and narrative synthesis. Genetics in Medicine, Article 101270.

CRISPR-Cas9

• Lau, C.-H., Liang, Q.-L., & Zhu, H. (2024). Next-generation CRISPR technology for genome, epigenome and mitochondrial editing. Transgenic Research. Advance online publication.
• Pandey, N., Arora, A., & Kumar, A. (2024). Genome editing tool CRISPR-Cas: Legal and ethical considerations for life science. In A. Kumar, S. Arora, S. Ogita, Y.-Y. Yau, & K. Mukherjee (Eds.), Gene Editing in Plants: CRISPR-Cas and Its Applications (pp. 839–864). Springer Nature.
• Wiley, L., Cheek, M., LaFar, E., Ma, X., Sekowski, J., Tanguturi, N., & Iltis, A. (2024). The ethics of human embryo editing via CRISPR-Cas9 technology: A systematic review of ethical arguments, reasons, and concerns. HEC Forum. Advance online publication.

Policy

• Browne, T. N., & Freeman, M. (2024). Next generation sequencing: Forensic applications and policy considerations. WIREs Forensic Science. Advance online publication.
• Majeed, S., Johnston, C., Saeedi, S., Mighton, C., Rokoszak, V., Abbasi, I., Grewal, S., Aguda, V., Kissoondoyal, A., Malkin, D., & Bombard, Y. (2024). International policies guiding the selection, analysis, and clinical management of secondary findings from genomic sequencing: A systematic review. The American Journal of Human Genetics. Advance online publication.