“I don’t need any more unknowns hanging over my head”: Cancer patients’ views on variants of uncertain significance and low/moderate risk results from genomic sequencing

Shickh and colleagues interviewed 25 patients who underwent cancer genomic sequencing as part of the Incidental Genomics Trial and found that the receipt of non-diagnostic results was associated with low perceptions of utility and could lead to hypervigilance about cancer symptoms. This was true unless their results were congruent with their family cancer history, or their impact was buffered by ongoing surveillance or support from family physicians or relatives.