Clinician-reported Genetic Testing Utility Index (C-GUIDE)
Year:
Hayeems and colleagues developed The Clinician-reported Genetic Testing Utility Index (C-GUIDE) to define and quantify the clinical utility of genetic testing. C-GUIDE was designed to capture the utility of a genetic test as it relates to (1) understanding diagnosis and prognosis, (2) informing medical management, (3) awareness and actionability of reproductive and health risks for patients and family members, and (4) overall patient and family well-being.
Research Population:
Citation:
Hayeems, R. Z., Luca, S., Ungar, W. J., Bhatt, A., Chad, L., Pullenayegum, E., & Meyn, M. S. (2020). The development of the clinician-reported genetic testing utility index (C-GUIDE): A novel strategy for measuring the clinical utility of genetic testing. Genetics in Medicine, 22(1), 95–101.
Validation(s)
Hayeems, R. Z., Luca, S., Xiao, B., Boswell-Patterson, C., Lavin Venegas, C., Abi Semaan, C. R., Kolar, T., Myles-Reid, D., Chad, L., Dyment, D., Boycott, K. M., Lazier, J., Ungar, W. J., & Armour, C. M. (2025). The Clinician-reported Genetic Testing Utility Index (C-GUIDE) for Prenatal Care: Initial evidence of content and construct validity. Genetics in Medicine, 27(1), Article 101306.
Hayeems, R. Z., Luca, S., Ungar, W. J., Venkataramanan, V., Tsiplova, K., Bashir, N. S., Costain, G., Inglese, C., McNiven, V., Quercia, N., Shugar, A., Yoon, G., Cytrynbaum, C., Dupuis, L., Shao, Z., Hewson, S., Shuman, C., Aul, R., Liston, E., Babul-Hirji, R., Bushby, A., Pullenayegum, E., Chad, L., & Meyn, M. S. (2022). The clinician-reported genetic testing utility index (C-GUIDE): Preliminary evidence of validity and reliability. Genetics in Medicine, 24(2), 430–438.