The Implementing GeNomics In PracTicE (IGNITE) Pragmatic Clinical Trials Network, is a network of research sites that support the implementation of genomics in healthcare by conducting pragmatic clinical trials. The IGNITE I network, ended in 2018, focused on designing methods for incorporating genomic medicine into clinical settings. The IGNITE II network is focused on delivering genomic medicine in real-world clinical settings.
Genomic research is rapidly expanding our knowledge about the genetic contributors to health and disease. A broad range of health benefits will flow from this research, including tests to predict disease risk and guide drug use, innovative therapies, and improved understanding of the interactions between genetic and environmental contributors to health. However, the specific benefits will vary for different diseases and populations, influenced by the nature of the genetic and non-genetic contributors, and the availability and safety of therapeutic options.