The Sulston Project is a joint research effort at Arizona State University and Baylor College of Medicine named after John Sulston, the champion of open science who, with Bob Waterston, crafted the Bermuda Principles for daily prepublication sharing of DNA sequence data in the Human Genome Project.  That open science ethos permeates genomics, but only incompletely.  Building an effective knowledge commons is essential for advancing knowledge and improving clinical care of those who inherit variants that increase their risk of cancer.