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In 2022 the US Supreme Court Dobbs vs. Jackson Women’s Health Organization overturned federal protection for abortion. This historic ruling not only relegates this authority to state legislatures but raises the possibility of restrictions on a range of reproductive technologies. Experts that joined this ELSI Friday Forum was reproductive endocrinologist and infertility specialist Sigal Klipstein and legal scholar and expert on assisted reproductive technologies Judith Daar on the changing regulatory landscape and the use of genomics in reproductive health.

PROJECT NARRATIVE Recent progress in complex trait genetics, coupled with the technical ability to generate accurate genome-wide genotypes from single-cell input, has made it possible to genetically screen embryos for common polygenic traits and disease risk. However, little empirical work has been done to quantify the utility of polygenic embryo screening (PES), examine its ethical implications, and assess stakeholder perspectives. The proposed study is designed to provide the necessary empirical basis for informed ethical discussion.

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