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This parent consent form was approved by the Institutional Review Board for the Baylor College of Medicine and Affiliated Hospitals for use in the Incorporation of Genomic Sequencing into Pediatric Cancer Care Study. The purpose of the study was learn how to report and use clinical exome sequencing test results for childhood cancer patients.

This parental consent form from the NCGENES: A Next-Generation Sequencing Platform for Genetic Diagnosis study is designed for the minor relatives of NCGENES study participants that received a genetic test result containing a variant of uncertain significance (VUS). This parental consent is for the minor relative to be tested for the VUS previously identified in the NCGENES study participant, not enrollment in the full NCGENES study.

This consent/ assent form for adults, adolescents, and parents of minors in the Personalized Medicine Based on Molecular Profiling of Patients with Cancer study includes consent to the use of tumor cells to create cell lines, consent to additional analysis of the sequencing data for research purposes, and "right not to know" provisions for results that may have significance for biological family members and results that may have potential medical impact.

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