PROJECT NARRATIVE The recent explosion in biobanking, more routine collection of data on gender identity, and rapid expansion of research in transgender and gender diverse (TGD) populations has afforded both an opportunity to study whether gender identity has genetic underpinnings, and a time sensitive need to inform how such research is used to benefit and not harm TGD populations.

PROJECT NARRATIVE Recent progress in complex trait genetics, coupled with the technical ability to generate accurate genome-wide genotypes from single-cell input, has made it possible to genetically screen embryos for common polygenic traits and disease risk. However, little empirical work has been done to quantify the utility of polygenic embryo screening (PES), examine its ethical implications, and assess stakeholder perspectives. The proposed study is designed to provide the necessary empirical basis for informed ethical discussion.