Developing Clinical Translational Tools to Communicate Genetic Risk to Individuals who are at Clinical High Risk for Psychosis
Institution: NEW YORK UNIVERSITY
FOA Number: PA-18-344
Abstract
While great strides are being made in identifying early signs that place people at a ?high risk state? for different illness conditions, at the same time, advances are being made in the identification of genes associated with ?high-risk states?. This study proposes to develop two innovative clinical tools that could greatly facilitate dissemination of a beneficial genetic malleability framing to high-risk youth in order to encourage increased treatment engagement and uptake of healthy behaviors. The impact of genetic information assumes special importance in the ?high-risk state? because achieving the best possible outcome is more likely if individuals actively choose to engage in beneficial treatment and health-promoting behaviors.
FUNDING AGENCY:
Funder:
NIH
Institute:
NATIONAL HUMAN GENOME RESEARCH INSTITUTE
Funding Type:
R21
Project Number:
R21HG010420
Start Date:
Aug 13, 2019
End Date:
Jul 31, 2021
PROJECT TERMS:
Abbreviations; Address; Age; Attenuated; base; Behavior; Behavioral; behavioral outcome; Belief; brca gene; Breast Cancer gene; Breast Cancer Risk Factor; Clinical; computerized; Computers; Control Groups; design; Development; Diabetes Mellitus; Diagnosis; Disease; Distant; Early Intervention; Effectiveness; efficacy testing; essentialism; Exposure to; Future; Gene Expression; Genes; Genetic; Genetic Determinism; genetic discrimination; genetic information; Genetic Risk; Goals; Health; Health Promotion; high risk; improved; improved outcome; Individual; innovation; Link; Literature; malleable risk; Manuals; modifiable risk; National Human Genome Research Institute; non-genetic; Outcome; Participant; prevent; Preventive; primary outcome; protective behavior; psychogenetics; Psychotic Disorders; Public Health; Randomized Clinical Trials; Research; response; Risk; Risk Behaviors; Risk Factors; risk variant; Safety; Sampling; secondary outcome; Self Management; social stigma; Stress; Testing; Time; tool; Training; uptake; Work; young adult; Youth