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NIH Sep 13, 2011 | R21
Genetic Education to Promote Counseling Attendance after Surgical Treatment
Institution: Moffitt Cancer Center
FOA Number: PA-10-069
Abstract
In 2009, 192,370 new cases of female breast cancer (BC) were diagnosed in the U.S. Of these cases, 5%- 10% were attributed to BRCA mutations. This translates to approximately 9,000 to 18,000 high-risk women who may be impacted by hereditary BC. In a given year, the number of high-risk BC patients is similar to or greater than the total number of cases of other cancers in women (e.g., oral cancer, n=10,480; stomach cancer, n=8,310; cervical cancer n=11,720; myeloma n=8,900). While, the relative proportion of BC patients at increased risk for hereditary BC may be considered small, the absolute number is comparable to the total number of female cases in certain cancer sites. Recent studies suggest BC patients with a BRCA mutation have a 3.5 to 4.5 times greater risk of contralateral breast cancer (CBC) than patients without a BRCA mutation. Thus, thousands of women each year not only face a current BC diagnosis but are also at significantly increased CBC risk. There are criteria put forth by several leading health and professional organizations including the National Comprehensive Cancer Network that help providers readily identify women at increased risk for hereditary BC(e.g., diagnosis
FUNDING AGENCY:
Funder:
NIHInstitute:
NATIONAL HUMAN GENOME RESEARCH INSTITUTEFunding Type:
R21Project Number:
R21HG006415Start Date:
Sep 13, 2011End Date:
Jun 30, 2013PROJECT TERMS:
Anxiety, base, BRCA1 gene, BRCA2 gene, BRCA2 Mutation, Breast, breast cancer diagnosis, breast cancer family, Cancer Center, cancer diagnosis, cancer genetics, Cancer Patient, cancer risk, cancer site, Caring, Chemopreventive Agent, Clinical, clinical care, clinical practice, Contralateral, Control Groups, Counseling, Data, Decision Making, design, Diagnosis, Distress, Early Diagnosis, early onset, Education, Face, Family Cancer History, Family history of, Feeling, Female, Female Breast Carcinoma, Future, Genetic, Genetic Counseling, Genetic screening method, Genetic Services, Goals, group intervention, health belief, health care consultation, Health Communication, health organization, Health Professional, Hereditary Breast and Ovarian Cancer Syndrome, Hereditary Breast Carcinoma, high risk, High Risk Woman, improved, Intention, Intervention, Knowledge, Letters, Mails, malignant breast neoplasm, malignant mouth neoplasm, Malignant neoplasm of cervix uteri, Malignant neoplasm of ovary, Malignant Neoplasms, malignant stomach neoplasm, Measures, Mediator of activation protein, meetings, Modeling, Multiple Myeloma, Mutation, National Comprehensive Cancer Network, Oncology, Operative Surgical Procedures, Ovary, Patients, Pattern, Phase, Physicians, post intervention, Predisposition, Prevention, Process, Professional counselor, Professional Organizations, Provider, psychoeducational intervention, psychosocial adjustment, Psychosocial Factor, Randomized Controlled Trials, Relative (related person), Research, Risk, Risk Assessment, Risk Factors, Risk Reduction, Risk Reduction Behavior, Sample Size, Selection for Treatments, Services, System, Testing, theories, therapy development, Time, Translating, Treatment Efficacy, trial comparing, tumor, uptake, Woman
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