NIH Sep 13, 2011 | R21

Genetic Education to Promote Counseling Attendance after Surgical Treatment

Principal Investigator(s): Vadaparampil, Susan

Institution: Moffitt Cancer Center

FOA Number: PA-10-069

Abstract

In 2009, 192,370 new cases of female breast cancer (BC) were diagnosed in the U.S. Of these cases, 5%- 10% were attributed to BRCA mutations. This translates to approximately 9,000 to 18,000 high-risk women who may be impacted by hereditary BC. In a given year, the number of high-risk BC patients is similar to or greater than the total number of cases of other cancers in women (e.g., oral cancer, n=10,480; stomach cancer, n=8,310; cervical cancer n=11,720; myeloma n=8,900). While, the relative proportion of BC patients at increased risk for hereditary BC may be considered small, the absolute number is comparable to the total number of female cases in certain cancer sites. Recent studies suggest BC patients with a BRCA mutation have a 3.5 to 4.5 times greater risk of contralateral breast cancer (CBC) than patients without a BRCA mutation. Thus, thousands of women each year not only face a current BC diagnosis but are also at significantly increased CBC risk. There are criteria put forth by several leading health and professional organizations including the National Comprehensive Cancer Network that help providers readily identify women at increased risk for hereditary BC(e.g., diagnosis

FUNDING AGENCY:

Funder:
NIH

Institute:
NATIONAL HUMAN GENOME RESEARCH INSTITUTE

Funding Type:
R21

Project Number:
R21HG006415

Start Date:
Sep 13, 2011

End Date:
Jun 30, 2013

PROJECT TERMS:

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