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NIH Sep 23, 2008 | R01
Patient perceptions of bioengineered probiotics and clinical metagenomics
Institution: Cleveland Clinic Lerner College of Medicine of Case Western Reserve University
FOA Number: RFA-RM-08-006
Abstract
The launch of the Human Microbiome Project (HMP), and the corresponding interest in bioengineered probiotic therapies that this new NIH initiative is likely to generate, provide a unique opportunity for research examining ethical and social considerations in the introduction of new therapeutic modalities. To date, analysis of ethical and social considerations in the use of probiotics have focused on "over the counter" applications where physician involvement in the selection and administration of the probiotic is limited. As new probiotic therapies become a part of the clinician's arsenel, it is important to consider how patients may perceive and respond to new probiotic therapies that are recommended by their physicians. To be successfully integrated into patient care, it is critical that patient attitudes and beliefs regarding bioengineered probiotics be well characterized. Studies of patient perceptions of therapeutic probiotics may reveal common misconceptions about probiotic therapies and/or widespead
concerns that may limit patient enthusiasm for new therapeutic options. This research project will characterize patient perceptions of bioengineered probiotics and other potential clinical applications of metagenomic analyses of the human microbiome. Empirical results from the project will be presented to a Working Group of national experts in gastroenterology, biomedical ethics, health policy, and patient advocacy, who will identify opportunities to promote the responsible introduction of bioengineered probiotics into the care of patients with debilitating gastrointestinal diseases. These strategies will focus on potential health-policy initiatives and educational interventions that gastroenterologists, patient educators, and voluntary-health organizations can undertake now in anticipation of the time when bioengineered probiotic therapies may be appropriate for routine clinical use.
PUBLIC HEALTH RELEVANCE: This research study will examine patient perceptions of bioengineered probiotics and other potential clinical applications of metagenomic analyses of the human microbiome. Systematic data on patient attitudes and beliefs about emerging therapeutic interventions facilitated by the Human Microbiome Project are critically important, as these data can identify potential barriers to the successful integration of bioengineered probiotics into patient care and improve physician-patient communication about new therapeutic options.
FUNDING AGENCY:
Funder:
NIHInstitute:
NATIONAL HUMAN GENOME RESEARCH INSTITUTEFunding Type:
R01Project Number:
R01HG004877Start Date:
Sep 23, 2008End Date:
Jul 31, 2011PROJECT TERMS:
Benefits and Risks, Bioethics, Biomedical Engineering, Classification, Clinical, clinical application, Communication, Data, Diagnostic, Educational Intervention, Emerging Technologies, Ethical Analysis, ethical legal social implication, Ethics, evidence base, Future, Gastroenterologist, Gastroenterology, Gastrointestinal Diseases, Health, Health Personnel, Health Policy, Human Microbiome, improved, interest, Life, Metabolic, Metagenomics, microbiome, Modality, Modeling, Neonatal, new technology, novel therapeutics, Patient advocacy, Patient Care, Patients, Perception, Perinatal, Physicians, population based, Probiotics, public health relevance, Request for Applications, Research, Research Project Grants, research study, social, Societies, Surveys, Technology, Therapeutic, Therapeutic Intervention, Time, Transplantation, United States National Institutes of Health, voluntary health organization, working group