The ELSI Friday Forum was held on Friday, March 10, 2023.
A growing number of private companies are offering prospective parents using in-vitro fertilization polygenic screening of embryos to identify the risks for developing complex diseases later in life. Children have already been born from IVF cycles that integrated this screening. The use of polygenic risk reports for children and adults in clinical care raises unique questions about parental reproductive freedom as well as the forces and societal values that mobilize this practice. What is the validity of polygenic screening? Should polygenic screening of embryos become a standard offering as part of IVF, alongside currently common screens for aneuploidies? What are the risks? How should the conditions for which polygenic screening of embryos are offered be determined, and by what criteria? This ELSI Friday Forum explores the ELSI challenges of polygenic screening of embryos and stakeholders’ perspectives on this emerging practice. We will discuss its risks, limitations, and potential benefits for families and society at large.
- Francesca Forzano, MD, FRCP (Guy's & St. Thomas' NHS Foundation Trust, King's College London)
- Gabriel Lázaro-Muñoz, PhD, JD (Harvard Medical School)
- Moderated by Anna Lewis, DPhil (Harvard University, Brigham and Women's Hospital)
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Videos in Series

ELSI Friday Forum - The Genomics of PTSD Risk: Scientific and Ethical Perspectives

ELSI Friday Forum - Population Descriptors in Genomic Research: Applying the NASEM Recommendations

ELSI Friday Forum - Legal and Policy Challenges to Privacy in the Post-Genomic and Post-Dobbs Era

ELSI Friday Forum - Value and Values in Payment for Gene Therapies

ELSI Friday Forum - Visual Storytelling in ELSI Research

ELSI Friday Forum - Indigenizing Genomics and Advancing Indigenous Data Sovereignty

ELSI Friday Forum - Wrestling with Social and Behavioral Genomics

ELSI Friday Forum - Genetic Advantages in Sports: When Do They Count as "Doping"?

ELSI Friday Forum - Genetics and AI: Group Privacy and Fairness

ELSI Friday Forum - Advocacy and Allyship in ELSI: Opportunities and Challenges

ELSI Friday Forum - Decoloniality and Genetic Ancestry: Situating the "African Genome"

ELSI Friday Forum - Legal Challenges to Newborn Screening Research

ELSI Friday Forum - Impact of SCOTUS's Dobbs Decision on Prenatal Genomics Research and Practice

ELSI Friday Forum - Addressing Algorithmic Harms: Practices and Provocations for Health AI

ELSI Friday Forum - Balancing Data Privacy and Data Sharing: Normative and Technical Approaches

ELSI Friday Forum - Genomic Imaginaries: Sparking Dialogue between ELSI and Literary Studies

ELSI Friday Forum - Ensuring Equitable Use of New Genetic Technologies: Lessons from Eugenics

ELSI Friday Forum - New ACMG Guidance on Carrier Screening: More or Less Equitable?

ELSI Friday Forum - Benefit-sharing and Pharmaceutical Development in Africa: What Does Equity Mean?
ELSI Friday Forum - Genomic Data Sharing: Putting Principles and Policy into Practice
ELSI Friday Forum - Current Legal Challenges to Abortion: Implications for Prenatal Genetics
ELSI Friday Forum - Ethical Challenges in Novel Gene Therapies for Sickle Cell Disease

ELSI Friday Forum - Widening the Lens: Using Arts in ELSI Research

ELSI Friday Forum - Migrant DNA: Context, Ethics and Legal Issues

ELSI Friday Forum - Genomics and Infectious Disease: Scientific and ELSI Issues of COVID

ELSI Friday Forum - ELSI Friday Forum: Biobanking in the Era of COVID

ELSI Friday Forum - Addressing Racism in Research and Clinical Practice
