Polygenic Risk Prediction in Diverse Populations and Contexts: Scientific and Ethical Considerations

This ELSI Friday Forum took place on January 12, 2024. 

The differential performance of polygenic risk scores (PRS) by population genetic background is a well-known scientific concern and one of the most important barriers to their equitable translation for clinical use. Not only must the social repercussions of how people are grouped for test development be considered, but the communication of their context specificity and differential performance to patients and their clinicians must be carefully managed. Drawing on recent research experiences with the development, validation, and implementation of PRS for common complex disease risk, this webinar will explore the scientific and ethical considerations relevant to the widespread adoption of PRS for clinical care.

Join the discussion with panelists Malia Fullerton, DPhil and Alicia Martin, PhD, moderated by Alham Saadat, MS.