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NIH May 16, 2020 | K01
Cost-effectiveness of Whole Genome Sequencing of Healthy Adults
Institution: HARVARD PILGRIM HEALTH CARE, INC.
FOA Number: PA-14-044
Abstract
PROJECT NARRATIVE The central goal of the proposed research is to determine the cost-effectiveness of integrating whole genome sequencing into the care of healthy adults. We will assess the health impact and cumulative healthcare costs of participants of a randomized clinical trial of whole genome sequencing five years after they received results, and we will extend these analyses over patients' lifetimes using decision analytic models. Findings will inform development of clinical guidelines and reimbursement strategies to accelerate the integration of sequencing into medical care.
FUNDING AGENCY:
Funder:
NIHInstitute:
NATIONAL HUMAN GENOME RESEARCH INSTITUTEFunding Type:
K01Project Number:
K01HG009173Start Date:
May 16, 2020End Date:
Jun 30, 2021PROJECT TERMS:
Address, Adult, Area, base, behavioral response, Benign, Big Data, career, career development, Caring, Classification, Clinical, clinical care, clinical development, Clinical Trials, Conduct Clinical Trials, cost, Cost Analysis, cost effective, cost effectiveness, Cost effectiveness research, Cost utility, Data, data modeling, Decision Making, Decision Modeling, Development, Diagnostic tests, Disclosure, Disease, disorder risk, DNA Sequence, economic implication, etiology, Evaluation, experience, falls, Family, follow-up, Foundational Skills, Foundations, Funding, Future, Genetic, genome sequencing, Genomics, Goals, Grant, Guidelines, Health, Health Care Costs, Health Expenditures, Health Technology, Healthcare, high risk, improved, Incidental Findings, Individual, Inherited, innovation, insight, Institution, instructor, International, Intervention, large datasets, Lead, Medical, mendelian disorder, Mentors, Modeling, Monitor, National Human Genome Research Institute, National Research Service Awards, novel, Outcome, Participant, Pathogenicity, Patient Care, Patient-Focused Outcomes, Patients, Peer Review, Penetrance, Periodicity, pharmacogenomics, Physicians, Policies, Population, Predisposition, Prevention, Primary Health Care, Principal Investigator, Process, programs, psychologic, Publications, Publishing, Quality-Adjusted Life Years, Randomized Clinical Trials, Randomized Controlled Trials, randomized trial, Recording of previous events, reproductive, Research, Research Personnel, Research Training, Reservations, response, Risk, screening, Services, side effect, skills, skills training, symposium, Syndrome, Technology Assessment, Testing, Time, treatment as usual, treatment choice, Uncertainty, United States National Institutes of Health, Variant, whole genome