• NIH Sep 1, 2003 | R01

    Neurobiological Predictors of Huntington's Disease

    Principal Investigator(s): Paulsen, Jane

    Institution: University of Iowa

    FOA Number: PA-12-100

    Abstract

    The proposal is a longitudinal study of potential neurobiological and neurobehavioral markers of disease onset and progression in pre-symptomatic individuals who have the CAG expansion in the HD gene. A total of 500 subjects will be enrolled. Study subjects will be 30 to 55 years old and have a parental history of Huntington's disease. The study will enroll 425 cases with >39 CAG repeats (affected), and 75 controls with . . . (supplement)

    FUNDING AGENCY:

    Funder:
    NIH

    Institute:
    NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

    Funding Type:
    R01

    Project Number:
    R01NS040068

    Start Date:
    Sep 1, 2003

    End Date:
    Aug 31, 2004

    PROJECT TERMS:

    Activities of Daily Living, Affect, Anisotropy, Award, Behavioral, Biological, Biological Markers, Brain imaging, CAG repeat, candidate identification, catalyst, Clinical, clinical Diagnosis, Clinical Trials, Cognitive, cohort, Collaborations, Companions, Corpus striatum structure, Databases, Development, Diagnosis, Disease, disease diagnosis, Disease Marker, Disease Progression, efficacy trial, etiology, functional disability, Functional disorder, Funding, Future, Genes, Genetic, Genetic screening method, Goals, Health, human Huntingtin protein, Huntington Disease, Image, improved, Individual, innovation, International, Knowledge, longitudinal course, Measurement, Measures, Modeling, Motor, multi-site trial, Natural History, Neurobiology, Neurodegenerative Disorders, neuroimaging, Neurologic, Observational Study, Onset of illness, Participant, Performance, Persons, Pharmaceutical Preparations, Phase, Phase I/II Trial, Plant Roots, Plasma, predictive modeling, prevent, Recruitment Activity, Research Infrastructure, Resources, Risk, Safety, Sample Size, Sampling, Site, Speed, Spottings, Staging, Standardization, Subjects Selections, Surrogate Endpoint, Symptoms, Testing, Therapeutic, Time, tool, Training, Validity and Reliability, volunteer, white matter

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