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NIH Jul 14, 2023 | K01
Managing the Uncertainty of Genetic Information in Neonates
Institution: CHILDREN'S HOSP OF PHILADELPHIA
FOA Number: PA-20-190
Abstract
PROJECT NARRATIVE Genetic testing is increasingly used in ill neonates and holds promise to improve care, but the uncertainty of many genetic results complicates their application to clinical practice and poses an important hazard. Uncertainty can lead both clinicians and parents to misunderstand or misapply findings, resulting in biased treatment plans. The proposed research is designed to identify the potential risks that emerge as neonatologists and parents interpret and apply uncertain genetic results, and to mediate these risks by developing a tool to improve the management and communication of results.
FUNDING AGENCY:
Funder:
NIHInstitute:
National Human Genome Research InstituteFunding Type:
K01Project Number:
1K01HG013114-01Start Date:
Jul 14, 2023End Date:
May 31, 2028PROJECT TERMS:
Decision making , genetic association, genetic counselor, exome sequencing, variant of unknown significance, feasibility testing, Neonatal Intensive Care Units, Newborn Infant, genetic disorder diagnosis, neonate
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