Psychosocial Aspects of Genetic Testing for HNPCC (II)

This application proposes three interrelated phases of research. The first phase will extend the prospective descriptive study of psychosocial aspects of molecular testing for HNPCC in colorectal cancer (CRC) cases, the first degree relatives (FDRs) of CRC cases who are found to be carriers of an HNPCC mutation, and spouses/partners (S/Ps) of the FDRs. The second phase will study the psychosocial issues related to participation in a phase II randomized, controlled chemoprevention trial for HNPCC involving adherence to a Cox II inhibitor and periodic check-ups over a 1 year period. The third phase will focus on the family as a unit of study for genetic testing and counseling. The study population is comprised of cases of adenocarcinoma of the colon or rectum seen at the University of Texas M.D. Anderson Cancer Center, FDRs of CRC cases who are found to be carriers of an HNPCC mutation, and the S/Ps of the FDRs. Outcome measures of the proposed research include: 1) donation of a blood sample for genetic testing; 2) willingness to inform relatives about HNPCC status; 3) completion of genetic counseling for test results disclosure; 4) psychological status/well being; and 5) adherence to recommended surveillance procedures. (Member of CGSC)